Pleurisy and methotrexate treatment.
نویسندگان
چکیده
منابع مشابه
The treatment of tuberculous pleurisy.
The object of treatment in tuberculous pleurisy is to shorten the acute phase of the illness, to restore the integrity of the pleura, and, above all, to prevent further manifestations of tuberculosis. Rest, chemotherapy, and aspiration are each supposed to achieve some of these aims, but their relative importance has not been established. The value of rest was stressed by Roper and Waring (1955...
متن کاملEffects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy.
BACKGROUND The model of pleurisy induced by carrageenan exhibits a biphasic response (4 and 48 h) and permits the quantification of exudate, cell migration and certain enzymes such as myeloperoxidase (MPO) and adenosine-deaminase (ADA) that are markers of activated leukocytes. AIMS The present study evaluates whether there exists, in the pleurisy model, a significant inhibition of ADA and MPO...
متن کاملMethotrexate Inhibits Integrin Adhesion Molecules in the Mouse Model of Pleurisy Induced by Carrageenan
The aim of this work was to analyze the effect of methotrexate (MTX) upon leukocyte migration and expression of adhesion molecules CD11a/CD18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. The results showed that MTX significantly decreased leukocyte influx and CD11a expression in the lung at 4 and 48 h of pleurisy (P < 0.01). MTX also inhibited CD18 expression at ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6091.867